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KMID : 0363320120330010083
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Journal of Korean Oriental Internal Medicine
2012 Volume.33 No. 1 p.83 ~ p.101
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Therapeutic Effect of Bogijetongtanggammi-bang on Peripheral Nerve Injury
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Kim Jin-Mi
Cho Chung-Sik
Kim Chul-Jung
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Abstract
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Objectives: This study was aimed to investigate the therapeutic effect of Bogijetongtanggammi-bang (BJTG) on injury of the peripheral nerve tissues.
Methods: Rats were divided into 2 groups. The rats of the first group were injected with Taxol (1.25 mg/kg) to their sciatic nerves, once each. The sciatic nerves of the rats of the second group were crushed by forcept for 30 seconds. Rats were administered with BJTG (400 mg/kg) or 0.9% saline for 5 days. Changes of DRG neurons, Schwann cells, Cdc2, caspase 3. phospho-p44/42 Erk1/2, phospho-vimentin and β1 integrin were observed by fluorescent microscope and analysed in western blot.
Results: In Taxol-treated SD rat models, BJTG up-regulated neurite outgrowth, Schwann cells, Cdc2 and phospho-Erk1/2, and down-regulated caspase 3. In pressure-injured rat models, BJTG up-regulated axons of sciatic nerve, Schwann cells, Cdc2, phospho-vimentin, β1 integrin, and down-regulated caspase 3.
Conclusions: Taken together, BJTG was promotive of nerve regeneration on SNI as well as Taxol-induced nerve injury. BJTG had a pharmaceutical property enhancing recovery of injured peripheral nerves and could be a candidate for drug development after further research.
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KEYWORD
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Bogijetongtanggammi-bang (BJTG), Taxol, sciatic nerve after injury (SNI), nerve regeneration
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